Identification of Two Serine Residues Essential for Agonist-Induced 5-HT2AReceptor Desensitization†
نویسندگان
چکیده
منابع مشابه
Identification of two serine residues essential for agonist-induced 5-HT2A receptor desensitization.
5-HT(2A) serotonin receptors represent the principal molecular targets for LSD-like hallucinogens and atypical antipsychotic drugs. It has been proposed that a dysregulation of 5-HT(2A) receptor-mediated signaling may contribute to the pathogenesis of schizophrenia and related diseases. A major mechanism for the attenuation of GPCR signaling following agonist activation typically involves the p...
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ژورنال
عنوان ژورنال: Biochemistry
سال: 2003
ISSN: 0006-2960,1520-4995
DOI: 10.1021/bi035061z